Vascular KCNQ channels in humans: the sub-threshold brake that regulates vascular tone?
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چکیده
منابع مشابه
Ion channels and vascular tone.
Ion channels in the plasma membrane of vascular muscle cells that form the walls of resistance arteries and arterioles play a central role in the regulation of vascular tone. Current evidence indicates that vascular smooth muscle cells express at least 4 different types of K(+) channels, 1 to 2 types of voltage-gated Ca(2+) channels, >/=2 types of Cl(-) channels, store-operated Ca(+) (SOC) chan...
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OBJECTIVE To date, the contribution of basal atrial natriuretic peptide (ANP) levels to resting vascular function in humans is unknown. In the present study we sought to investigate the role of ANP in regulating regional vascular volume and venous tone in healthy subjects. METHODS AND RESULTS We used radionuclide plethysmography to examine the effects of ANP and the ANP-receptor antagonist A7...
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Several types of potassium (K+) channels are present in cerebral blood vessels. Opening or closure of these ion channels may have significant effects on membrane po tential, which is a major determinant of entry of extra cellular calcium and thus vascular tone, Because of the ionic properties of the cell membrane at rest, the change in activity of only a few K+ channels is sufficient to chang...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2010
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2010.01065.x